Ahmed Abdelfatah SEDIK

Assistant Professor & Senior Research Scientist in Pharmacology
Cairo, EG.

About

Highly accomplished Assistant Professor and Senior Research Scientist with over a decade of experience in pharmacology, biomedical sciences, and neuroscience. Spearheaded over 50 impactful publications in high-impact factor journals and secured significant research funding, driving advancements in therapeutic mechanisms and drug discovery. Proven leader in academic instruction, project management, and mentorship, dedicated to fostering scientific innovation and global collaboration.

Work

6 October University
|

Assistant Professor, Faculty of Applied Health Science Technology

6 October City, Egypt, Egypt

Summary

Leads pharmacology courses for undergraduate and postgraduate students, integrating advanced research insights into academic instruction and fostering scientific development.

Highlights

Delivered comprehensive pharmacology courses to undergraduate and postgraduate students since 2023, enhancing curriculum with current research findings.

Mentored numerous undergraduate, MSc, and PhD students in pharmacology and biomedical research, guiding them through research design and publication strategies.

Organized and taught advanced pharmacology techniques to students from multiple universities through summer training programs, impacting over 50 participants annually.

Contributed to the development of future scientists by providing foundational lab and pharmacological training to university students.

Clermont Auvergne University
|

Postdoctoral Researcher (Planned)

Clermont-Ferrand, Auvergne-Rhône-Alpes, France

Summary

Scheduled to conduct advanced postdoctoral research, focusing on novel therapeutic mechanisms and drug development within an international academic framework.

Highlights

Anticipated to contribute to cutting-edge research projects, leveraging expertise in pharmacology and experimental design.

Expected to collaborate with international research teams, enhancing global scientific partnerships and knowledge exchange.

National Research Centre
|

Researcher, Pharmacology Department, Medical Research and Clinical Studies Institute

Cairo, Egypt, Egypt

Summary

Conducted extensive pharmacological research, leading numerous projects and contributing significantly to over 50 publications in high-impact scientific journals.

Highlights

Authored and co-authored over 50 peer-reviewed publications, many in journals with Impact Factors up to 5.8, advancing knowledge in disease mechanisms and therapeutic interventions.

Led multiple scientific projects as Principal Investigator, including a STDF-funded project on otoferlin in neuropathic pain and NRC-funded projects on DPP-4 inhibitors and cancer biology.

Managed complex research initiatives from experimental design to data analysis and manuscript preparation, ensuring rigorous scientific methodology and impactful outcomes.

Secured significant funding from STDF and NRC for various research projects, demonstrating strong grant writing and project management capabilities.

National Research Centre
|

Assistant Researcher, Department of Pharmacology, Medical Research and Clinical Studies Institute

Cairo, Egypt, Egypt

Summary

Supported pharmacology research projects, specializing in experimental design, data analysis, and contributing to multiple peer-reviewed publications.

Highlights

Contributed to numerous research projects, applying advanced molecular and behavioral techniques to investigate drug mechanisms and disease pathophysiology.

Assisted in the preparation and submission of scientific manuscripts, ensuring accuracy and adherence to journal guidelines, leading to multiple co-authored publications.

Developed expertise in rodent behavioral assays and histological imaging, enhancing experimental rigor and data interpretation.

Collaborated effectively within research teams, facilitating project execution and contributing to a productive scientific environment.

National Research Centre
|

Research Assistant, Department of Pharmacology, Medical Research and Clinical Studies Institute

Cairo, Egypt, Egypt

Summary

Provided critical support for pharmacological studies, gaining foundational experience in laboratory techniques, data collection, and preliminary analysis.

Highlights

Executed various laboratory experiments, accurately collecting and documenting data to support ongoing pharmacological research projects.

Maintained laboratory equipment and ensured adherence to safety protocols, contributing to a secure and efficient research environment.

Assisted in preliminary data analysis using software like GraphPad Prism and SPSS, developing foundational skills in scientific data interpretation.

Collaborated with senior researchers on project tasks, gaining hands-on experience in research methodology and experimental execution.

National Research Centre
|

Demonstrator, Department of Pharmacology, Medical Research and Clinical Studies Institute

Cairo, Egypt, Egypt

Summary

Provided practical instruction and support for pharmacology students in laboratory settings, ensuring effective learning and skill development.

Highlights

Instructed undergraduate students in fundamental pharmacology laboratory techniques, fostering practical skills and understanding of experimental procedures.

Assisted in preparing and setting up laboratory sessions, ensuring all necessary materials and equipment were available and functional.

Provided one-on-one and group guidance to students, clarifying concepts and troubleshooting experimental challenges.

Evaluated student performance in practical sessions, contributing to their academic assessment and skill progression.

Volunteer

ALBA Network – Diversity in Neuroscience
|

Member

Summary

Engaged in initiatives to promote inclusivity, equity, and support for underrepresented scientists in neuroscience, participating in online events and discussions focused on equitable research practices and global collaboration.

Highlights

Actively participated in discussions and initiatives aimed at promoting diversity and inclusion within the neuroscience community.

Contributed to online events focused on equitable research practices, fostering a more inclusive global scientific ecosystem.

Helwan University
|

Awareness Day Organizer

Summary

Organized awareness campaigns on critical public health issues, including the effects of heavy metals and COVID-19 on human health.

Highlights

Coordinated awareness events at Helwan University regarding the impact of heavy metals on human health, educating the community on environmental toxicology.

Led public awareness initiatives on the noxious effects of COVID-19, providing vital health information and promoting preventative measures.

STEM Students Program – El Obour Branch
|

Trainer

Summary

Delivered hands-on pharmacology and biomedical science sessions to high school STEM students as part of a national innovation initiative.

Highlights

Engaged high school students in hands-on pharmacology and biomedical science, inspiring interest in STEM fields.

Contributed to a national innovation initiative by fostering scientific curiosity and practical skills among young learners.

Peer-Reviewed Journals
|

Reviewer

Summary

Served as a reviewer for multiple scientific journals in pharmacology, toxicology, and biomedical sciences, offering constructive feedback to improve manuscript quality and support the global scientific ecosystem.

Highlights

Provided critical peer review for numerous manuscripts in pharmacology, toxicology, and biomedical sciences, ensuring scientific rigor and quality.

Contributed to upholding publication standards and advancing the integrity of scientific literature.

National Research Centre & Virtual Academic Platforms
|

Organizer of Student Workshops and Research Training Seminars

Summary

Designed and delivered training sessions on experimental pharmacology methods, systematic reviews, and drug discovery at the National Research Centre and via virtual academic platforms.

Highlights

Developed and led workshops on experimental pharmacology, systematic reviews, and drug discovery, training hundreds of students and researchers.

Enhanced research capabilities of participants through hands-on training and theoretical sessions on advanced scientific methodologies.

Education

Cairo University
Cairo, Egypt, Egypt

PhD

Pharmacology

Cairo University
Cairo, Egypt, Egypt

MSc

Pharmacology

Benha University
Benha, Egypt, Egypt

Bachelor

Veterinary Sciences

Awards

Medical Research and Clinical Studies Institute, NRC, Award for Highest Publisher

Awarded By

National Research Centre (NRC)

Recognized for achieving the highest number of publications in 2024 within the Medical Research and Clinical Studies Institute.

STDF Excellence for Scientific Collaboration with AUTM

Awarded By

Science, Technology & Innovation Funding Authority (STDF)

Awarded for excellence in achieving scientific collaboration with AUTM on a technology transfer innovative scientific project.

NRC Award for Best National and Applicable Project Publishing

Awarded By

National Research Centre (NRC)

Received for the BurnCare gel product, recognized as the best national and applicable project publication.

NRC Award for Best International Publishing

Awarded By

National Research Centre (NRC)

Awarded for achieving the best international scientific publication among NRC researchers.

Fulbright Award for Best Innovative Scientific Project

Awarded By

Fulbright Commission

Recognized for an innovative scientific project, demonstrating significant potential for impact and originality.

Publications

The impact of Nrf2/HO-1, PD-L1/Bax/Bcl-2 and TNF-a/Il-6 signaling pathways in the ameliorative role of cordycepin against acrylamide-induced cardiac toxicity in rats.

Published by

Scientific Reports

Summary

Investigated the ameliorative role of cordycepin against acrylamide-induced cardiac toxicity in rats, elucidating its impact on Nrf2/HO-1, PD-L1/Bax/Bcl-2, and TNF-a/Il-6 signaling pathways.

Unravelling the mechanism by which vildagliptin and linagliptin inhibit pyroptosis in lung injury through the NLRP3 inflammatory pathway in type 1 diabetic rats.

Published by

Scientific Reports

Summary

Explored the mechanisms by which vildagliptin and linagliptin inhibit pyroptosis in lung injury in type 1 diabetic rats, focusing on the NLRP3 inflammatory pathway.

Insight into novel therapeutic targets in heart failure: a comprehensive review.

Published by

Journal of Basic and Clinical Physiology and Pharmacology

Summary

Provided a comprehensive review of novel therapeutic targets for heart failure, offering insights into future treatment strategies.

Neuroprotective effect of chicoric acid-loaded liposome nanoparticles against AlCl3-induced neurotoxicity in rats: insights into the role of AMPK/AKT/Nrf-2 signaling pathway.

Published by

NeuroToxicology

Summary

Investigated the neuroprotective effects of chicoric acid-loaded liposome nanoparticles against AlCl3-induced neurotoxicity in rats, highlighting the involvement of AMPK/AKT/Nrf-2 signaling pathways.

Chrysin mitigates cyclophosphamide-triggered cardiotoxicity in rats: Insights into cardioprotection via Treg expression modulation and iNOS downregulation.

Published by

Toxicology Reports

Summary

Demonstrated how chrysin mitigates cyclophosphamide-triggered cardiotoxicity in rats through Treg expression modulation and iNOS downregulation.

Ovario-protective effect of Moringa oleifera leaf extract against cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats.

Published by

Scientific Reports

Summary

Evaluated the ovario-protective effect of Moringa oleifera leaf extract against cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats (IF: 3.8).

Neuroprotective and cognitive enhancing effects of herbecetin against thioacetamide induced hepatic encephalopathy in rats via upregulation of AMPK and SIRT1 signaling pathways.

Published by

Scientific Reports

Summary

Investigated the neuroprotective and cognitive enhancing effects of herbecetin against thioacetamide-induced hepatic encephalopathy in rats, mediated by AMPK and SIRT1 signaling pathways (IF: 3.8).

Novel drugs affecting diabetic peripheral neuropathy.

Published by

Iranian Journal of Basic Medical Sciences

Summary

Reviewed novel drugs affecting diabetic peripheral neuropathy, providing an overview of current and emerging therapeutic strategies (IF: 2.1).

Immunoregulatory role of hesperidin against ovalbumin (OVA)-induced bronchial asthma and depression in rats.

Published by

Naunyn-schmiedeberg's Archives of Pharmacology

Summary

Examined the immunoregulatory role of hesperidin against ovalbumin (OVA)-induced bronchial asthma and associated depression in rats (IF: 3.1).

Mitigating effect of ferulic acid on di-(2-ethylhexyl) phthalate-induced neurocognitive dysfunction in male rats with a comprehensive in silico survey.

Published by

Naunynschmiedeberg's Archives of Pharmacology

Summary

Investigated the mitigating effect of ferulic acid on di-(2-ethylhexyl) phthalate-induced neurocognitive dysfunction in male rats, supported by in silico analysis (IF: 3.1).

Lauric acid attenuates hepato-metabolic complications and molecular alterations in high-fat diet-induced nonalcoholic fatty liver disease in rats.

Published by

Toxicology Mechanisms and Methods

Summary

Demonstrated how lauric acid attenuates hepato-metabolic complications and molecular alterations in high-fat diet-induced nonalcoholic fatty liver disease in rats (IF: 3.1).

Attenuation of sodium fluoride-induced hepatic injury by Lactobacillus casei through inhibition of NF-kß signalling pathway with decreased expression of caspase-3 in rats.

Published by

Egyptian Journal of Chemistry

Summary

Explored the attenuation of sodium fluoride-induced hepatic injury by Lactobacillus casei via inhibition of the NF-κB signaling pathway and decreased caspase-3 expression in rats (IF: 1.29).

Cold plasma approach fortifies the topical application of thymoquinone intended for wound healing via upregulating the levels of TGF-ß, VEGF, and a-SMA in rats.

Published by

International Immunopharmacology

Summary

Investigated how cold plasma enhances the topical application of thymoquinone for wound healing by upregulating TGF-β, VEGF, and α-SMA levels in rats (IF: 4.8).

Synergistic effect of arginine and Lactobacillus plantarum against potassium dichromate induced-acute liver and kidney injury in rats: Role of iNOS and TLR4/NF-kB signaling pathways.

Published by

Iranian Journal of Basic Medical Sciences

Summary

Analyzed the synergistic effect of arginine and Lactobacillus plantarum against potassium dichromate-induced acute liver and kidney injury in rats, focusing on iNOS and TLR4/NF-kB signaling pathways (IF: 2.1).

Dose-dependent toxic effects of di-(2-ethylhexyl) phthalate in male rats : Focus on behavioral alterations and inducing TLR4/NF-kB signaling pathway.

Published by

Toxicology and Applied Pharmacology

Summary

Studied the dose-dependent toxic effects of di-(2-ethylhexyl) phthalate in male rats, with a focus on behavioral alterations and the induction of the TLR4/NF-kB signaling pathway (IF: 3.3).

Neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats : targeting Nrf2 signaling pathway, inflammatory mediators, and apoptosis.

Published by

Inflammopharmacology

Summary

Investigated the neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats, targeting the Nrf2 signaling pathway, inflammatory mediators, and apoptosis (IF: 4.6).

Chitosan tamarind-based nanoparticles as a promising approach for topical application of curcumin intended for burn healing: in vitro and in vivo study.

Published by

Journal of Drug Targeting

Summary

Developed chitosan tamarind-based nanoparticles as a promising approach for topical application of curcumin for burn healing, validated through in vitro and in vivo studies (IF: 4.3).

Neuromodulatory role of Larginine: Nitric oxide precursor against thioacetamide-induced-hepatic encephalopathy in rats via downregulation of NF-kB-mediated apoptosis.

Published by

Environmental Science and Pollution Research

Summary

Explored the neuromodulatory role of L-arginine as a nitric oxide precursor against thioacetamide-induced hepatic encephalopathy in rats, mediated by downregulation of NF-kB-mediated apoptosis (IF: 5.8).

Febuxostat attenuates aluminum chloride-induced hepatorenal injury in rats with the impact of Nrf2, Crat, Car3, and MNK-mediated apoptosis.

Published by

Environmental Science and Pollution Research

Summary

Investigated how febuxostat attenuates aluminum chloride-induced hepatorenal injury in rats, focusing on the impact of Nrf2, Crat, Car3, and MNK-mediated apoptosis (IF: 5.8).

Modulatory effects of cilostazol; An Nrf2/HO-1 activator against NAFLD in rats confirmed by molecular docking and FTIR studies.

Published by

Egyptian Journal of Chemistry

Summary

Examined the modulatory effects of cilostazol as an Nrf2/HO-1 activator against NAFLD in rats, supported by molecular docking and FTIR studies (IF: 1.29).

Modulation activity of vildagliptin on hepatic complications and lipoprotein abnormalities associated with insulin resistance in rats.

Published by

Egyptian Journal of Chemistry

Summary

Investigated the modulation activity of vildagliptin on hepatic complications and lipoprotein abnormalities associated with insulin resistance in rats (IF: 1.29).

Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats : behavioral, biochemical, and ultrastructural evidence.

Published by

Canadian Journal of Physiology and Pharmacology

Summary

Provided behavioral, biochemical, and ultrastructural evidence for the synergistic effect of aminoguanidine and L-carnosine against thioacetamide-induced hepatic encephalopathy in rats (IF: 2.27).

Trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats.

Published by

Canadian Journal of Physiology and Pharmacology

Summary

Demonstrated how trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats (IF: 2.27).

Beneficial effect of trigonelline on the metabolic changes associated with insulin resistance in rats.

Published by

World J Pharm Pharm Sci

Summary

Evaluated the beneficial effect of trigonelline on metabolic changes associated with insulin resistance in rats (IF: 2.27).

Languages

Arabic
English

Skills

Histology & Imaging

Immunohistochemistry, Microscopy, Tissue sectioning.

Behavioral Neuroscience

Rodent behavioral assays.

Data Analysis

GraphPad Prism, ImageJ, SPSS.

Software

EndNote, Zotero, PyMOL, ChemDraw.

Research Methodologies

Experimental Design, Systematic Reviews, Drug Discovery, In vitro studies, In vivo studies, In silico analysis.

Project Management

Scientific Project Leadership, Grant Acquisition, Team Collaboration, Timeline Management.

Academic & Teaching

Curriculum Development, Lecturing, Mentorship, Student Training, Laboratory Instruction, Assessment.

Scientific Communication

Manuscript Preparation, Peer Review, Presentation Skills, Scientific Writing.

Molecular Techniques

qPCR, Western blot, RT-PCR.

Interests

Professional Affiliations

ALBA Network (FENS), The Association with Collaboration as its Core (IAOP, M11401), American Society for Microbiology, Pharmacological and Pharmaceutical Sciences Committee, UNESCO OWSD (Organization For Women In Science For The Developing World), The Arab Society for Medical Research (899), Egyptian Society of Toxicology (1018).

Projects

Role of otoferlin in neuropathic pain in mice

Summary

Principal Investigator (PI) for a scientific project jointly funded by STDF (Egypt) and IFE (France). Project Number: 49300.

DPP4 Inhibitors Evaluation of the Mechanistic Link between Dipeptidyl Peptidase-4 (DPP-4) Inhibitors and Cancer Biology in Diabetic Rats

Summary

Principal Investigator (PI) for a scientific project funded by NRC, Egypt. Project Number: 130601101.

Egyptian – US Collaboration Project

Summary

Principal Investigator (PI) for a collaborative project funded by STDF, Egypt. Project Number: 49709.

Laser Nanophotonics for Photoimmunotherapy and Immunofluorescence Imaging of Cancer

Summary

Member of a scientific project funded by NRC. Project Number: 13020302 / 10010308.

Synthesis, Characterization, Docking Studies, and Evaluation of Novel Bioactive Derivatives of Imidazole and/or Thiazole Nanoparticles as Antimicrobial and/or Anticancer Agents

Summary

Member of a scientific project funded by NRC. Project Number: 13010106.

Applying Plant Biotechnology Techniques to Increase Production of Natural Materials from Astragalus Plant

Summary

Member of a scientific project funded by NRC focused on preventing side effects from viral pathogens. Project Number: 13020112.

STDF Fund in Collaboration with AUTM, USA

Summary

Secured funding for a collaborative project with AUTM, USA, focusing on technology transfer and innovation.

NRC Fund for Internal Projects

Summary

Secured internal funding from the National Research Centre (NRC) for various research initiatives.